CytImmune’s tumor-targeting technology is highly versatile and may be used for the safe and systemic administration of drugs that traffic directly to the site of disease -- avoiding uptake by or accumulation in healthy organs and surrounding tissues.
The Company’s nano-scale development strategy is to engineer new colloidal gold-based drug compounds which harness the therapeutic potential of potent anti-cancer agents, limit their biodistribution primarily to tumor sites, and add to TNF’s biological actions. This core platform is the key to realizing improved patient outcomes.
CytImmune’s approach offers the potential to enable and/or expand the clinical benefit of a variety of toxic agents (such as tumor necrosis factor alpha (TNF), interleukins/interferons, monoclonal antibodies, chemotherapeutic agents, etc.) which may be used to treat multiple types of solid tumors -- either as monotherapies or in combination with existing standards of care. The Company¹s nanomedicines function independent of tumor specific biochemistry and, therefore, do not depend on the type of cancer treated.
Having completed dosing of its Phase 1 trial, the early clinical data indicate that: (1) CytImmune safely and systemically delivered TNF in humans far beyond concentrations attained in previous human studies and (2) based on tissue biopsies from treated patients, Aurimune accumulates in and around tumor sites, avoids uptake by the liver and spleen, and is essentially absent from surrounding healthy tissues.
"Gold Nanoparticle" Video
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"Making Colloidal Gold" Animation 112K | 384K
"How Technology Works" Animation 112K | 384K
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